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The chemistry of sleep

National Curriculum links (Key Stage 4 double science)
Sc1
1c
... ways in which scientific work may be affected by the contexts in which it takes place and how these contexts may affect whether or not these ideas are accepted
Sc3
3h
... the properties, reactions and uses of the halogens

Resources

Ethanol – the earliest anaesthetic? gives students a brief introduction into the development of surgery until the barber surgeons, and the limitations imposed by operating on patients with only ethanol (in the form of spirits like brandy) as anaesthetic/pain relief.

The arrival of effective anaesthetics introduces students to the competing claims over the discovery of ether as an anaesthetic, and provides information about three other anaesthetics discovered in the 1840s.

Modern anaesthetics focuses on three modern anaesthetics – enflurane, isoflurane and halothane. It emphasises the role of chemists in the development of anaesthetics, and the role of halogen atoms and the strength of the carbon-fluorine bond in producing a good, safe anaesthetic.

Activities

Activity 1  
  • Questions about the molecular structures of anaesthetic molecules.
Activity 2  
  • Questions about the physical properties of anaesthetics.
Activity 3  
  • Students are asked to put themselves in the shoes of William Morton, one of the pioneers of the use of ether in dental surgery. They should EITHER write a short article for the press explaining the exciting new treatment and all its potential OR produce a poster for the press and the dentist’s surgery. You may choose to give students a free choice or direct them to one or other activity. The aim is to encourage them to recognise the enormous step forward that surgery with effective anaesthetic presented. Look for evidence that they recognise the hopes and fears that a "chemical sleep" would arouse in ordinary people – and how Morton might try to assuage those fears.
 
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