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The Chinese calculate the length of the solar year as about 365.25
days.
Influenza ('flu) is recorded as a disease for the first time
in Paris in 1414.
Between 1440 and 1449 Nicholas of Cusa (a German whose
real name was Nicholas Krebs) writes a book suggesting
amongst other things that the earth revolves around the Sun. He
also makes glasses for near-sighted people.
Leonardo da Vinci designs a working parachute.
An 'anatomical theatre' is opened in Padua, Italy where people
can go to see the dissection of corpses demonstrated. This isparticularly
useful for doctors and trainee doctors who for the first time
can see what the insides of people look like and try to relate
what they see to the symptoms living patients might describe.
Christopher Columbus discovers that Native Americans use
tobacco as a medicine. 
Leonardo da Vinci is the first person to observe capillary
action when he notices that liquids in tubes of small diameter
tend to move up the walls of the tubes.
In 1500 the Chinese scientist Wan Hu ties 47 gunpowder
rockets to a chair in an effort to make a flying machine, but
it explodes and kills him! 
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